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Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid

Dorn, Christoph ; Petroff, David ; Stoelzel, Melanie ; Kees, Martin G. ; Kratzer, Alexander ; Dietrich, Arne ; Kloft, Charlotte ; Zeitlinger, Markus ; Kees, Frieder ; Wrigge, Hermann ; Simon, Philipp


Objectives: To assess plasma and tissue pharmacokinetics of cefazolin and metronidazole in obese patients undergoing bariatric surgery and non-obese patients undergoing intra-abdominal surgery. Patients and methods: Fifteen obese and 15 non-obese patients received an IV short infusion of 2g cefazolin and 0.5g metronidazole for perioperative prophylaxis. Plasma and microdialysate from subcutaneous ...


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