Loss of PKGIβ/IRAG1 Signaling Causes Anemia-Associated Splenomegaly

URN to cite this document:: urn:nbn:de:bvb:355-epub-456900
DOI to cite this document:: 10.5283/epub.45690

Schlossmann, Jens ; Majer, Michael ; Prueschenk, Sally

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Date of publication of this fulltext: 25 May 2021 08:38

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Abstract

Inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate 1 (IRAG1) is a substrate protein of the NO/cGMP-signaling pathway and forms a ternary complex with the cGMP-dependent protein kinase I beta (PKGI beta) and the inositol triphosphate receptor I (IP3R-I). Functional studies about IRAG1 exhibited that IRAG1 is specifically phosphorylated by the PKGI beta, regulating cGMP-mediated ...