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Prolonged suppression of butyrate producing bacteria is associated with acute gastrointestinal graft-versus-host disease and transplant related mortality after allogeneic stem cell transplantation

Meedt, Elisabeth ; Hiergeist, Andreas ; Gessner, André ; Dettmer, Katja ; Liebisch, Gerhard ; Ghimire, Sakhila ; Poeck, Hendrik ; Edinger, Matthias ; Wolff, Daniel ; Herr, Wolfgang ; Holler, Ernst ; Weber, Daniela


Butyrogenic commensals diminish early after allogeneic stem cell transplantation. This is significant because bacterial metabolites such as butyrate have important anti-inflammatory functions and stabilizing effects on gut epithelial integrity. Accordingly, loss of butyrogenic bacteria is associated with increased severity of graft-vs-host disease and increased transplantation-related mortality. ...


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