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Prolonged suppression of butyrate producing bacteria is associated with acute gastrointestinal graft-versus-host disease and transplant related mortality after allogeneic stem cell transplantation

Meedt, Elisabeth ; Hiergeist, Andreas ; Gessner, André ; Dettmer, Katja ; Liebisch, Gerhard ; Ghimire, Sakhila ; Poeck, Hendrik ; Edinger, Matthias ; Wolff, Daniel ; Herr, Wolfgang ; Holler, Ernst ; Weber, Daniela


Background Butyrogenic bacteria play an important role in gut microbiome homeostasis and intestinal epithelial integrity. Previous studies have demonstrated an association between administration of short chain fatty acids like butyrate and protection from acute graft-versus-host disease (aGvHD) after allogeneic stem cell transplantation (ASCT). Methods Here we examined the abundance and ...


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