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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-463898
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.46389
Zusammenfassung
Treatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4(+) T cells (T-EM cells). Pre-therapy CD4(+) T-EM cell expansion occurs primarily during autumn or winter in ...
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