Go to content
UR Home

Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole

Fleming, Jennifer R. ; Schupfner, Michael ; Busch, Florian ; Baslé, Arnaud ; Ehrmann, Alexander ; Sterner, Reinhard ; Mayans, Olga


Tryptophan synthase (TrpS) is a heterotetrameric alpha beta beta alpha enzyme that exhibits complex substrate channeling and allosteric mechanisms and is a model system in enzymology. In this work, we characterize proposed early and late evolutionary states of TrpS and show that they have distinct quaternary structures caused by insertions-deletions of sequence segments (indels) in the ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons