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Splicing and Chromatin Factors Jointly Regulate Epidermal Differentiation

Tanis, Sabine E.J. ; Jansen, Pascal W.T.C. ; Zhou, Huiqing ; van Heeringen, Simon J. ; Vermeulen, Michiel ; Kretz, Markus ; Mulder, Klaas W.



Abstract

Epidermal homeostasis requires balanced progenitor cell proliferation and loss of differentiated cells from the epidermal surface. During this process, cells undergo major changes in their transcriptional programs to accommodate new cellular functions. We found that transcriptional and post-transcriptional mechanisms underlying these changes jointly control genes involved in cell adhesion, a key ...

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