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Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion

Uchida, Hitoshi ; Matsumura, Shinji ; Katano, Tayo ; Watanabe, Masahiko ; Schlossmann, Jens ; Ito, Seiji


cGMP-dependent kinase-I (cGKI) is known to regulate spinal pain processing. This enzyme consists of two isoforms (cGKI alpha and cGKI beta) that show distinct substrate specificity and tissue distribution. It has long been believed that the alpha isoform is exclusively expressed in the adult dorsal root ganglion. The aim of the present study was to reexamine the expression of cGKI isoforms in the ...


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