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Shared genetic etiology between alcohol dependence and major depressive disorder

Foo, Jerome C. ; Streit, Fabian ; Treutlein, Jens ; Ripke, Stephan ; Witt, Stephanie H. ; Strohmaier, Jana ; Degenhardt, Franziska ; Forstner, Andreas J. ; Hoffmann, Per ; Soyka, Michael ; Dahmen, Norbert ; Scherbaum, Norbert ; Wodarz, Norbert ; Heilmann-Heimbach, Stefanie ; Herms, Stefan ; Cichon, Sven ; Preuss, Ulrich ; Gaebel, Wolfgang ; Ridinger, Monika ; Hoffmann, Sabine ; Schulze, Thomas G. ; Maier, Wolfgang ; Zill, Peter ; Müller-Myhsok, Bertram ; Ising, Marcus ; Lucae, Susanne ; Nöthen, Markus M. ; Mann, Karl ; Kiefer, Falk ; Rietschel, Marcella ; Frank, Josef


The clinical comorbidity of alcohol dependence (AD) and major depressive disorder (MDD) is well established, whereas genetic factors influencing co-occurrence remain unclear. A recent study using polygenic risk scores (PRS) calculated based on the first-wave Psychiatric Genomics Consortium MDD meta-analysis (PGC-MDD1) suggests a modest shared genetic contribution to MDD and AD. Using a ...


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