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Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance

Ridinger, Johannes ; Koeneke, Emily ; Kolbinger, Fiona R. ; Koerholz, Katharina ; Mahboobi, Siavosh ; Hellweg, Lars ; Gunkel, Nikolas ; Miller, Aubry K. ; Peterziel, Heike ; Schmezer, Peter ; Hamacher-Brady, Anne ; Witt, Olaf ; Oehme, Ina


Drug resistance is a leading cause for treatment failure in many cancers, including neuroblastoma, the most common solid extracranial childhood malignancy. Previous studies from our lab indicate that histone deacetylase 10 (HDAC10) is important for the homeostasis of lysosomes, i.e. acidic vesicular organelles involved in the degradation of various biomolecules. Here, we show that depleting or ...


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