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[(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G(2)/M phase and apoptosis

Pojarová, Michaela ; Kaufmann, Doris ; Gastpar, Robert ; Nishino, Tsuyuki ; Reszka, Przemyslaw ; Bednarski, Patrick J. ; Angerer, Erwin von


Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with malononitrile. The resulting methylene propanedinitriles inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values below 100 nM. Though they exhibited similar structure-activity ...


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