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Are Metabolic Signatures Mediating the Relationship between Lifestyle Factors and Hepatocellular Carcinoma Risk? Results from a Nested Case–Control Study in EPIC

Assi, Nada ; Thomas, Duncan C. ; Leitzmann, Michael ; Stepien, Magdalena ; Chajès, Véronique ; Philip, Thierry ; Vineis, Paolo ; Bamia, Christina ; Boutron-Ruault, Marie-Christine ; Sandanger, Torkjel M. ; Molinuevo, Amaia ; Boshuizen, Hendriek C. ; Sundkvist, Anneli ; Kühn, Tilman ; Travis, Ruth C. ; Overvad, Kim ; Riboli, Elio ; Gunter, Marc J. ; Scalbert, Augustin ; Jenab, Mazda ; Ferrari, Pietro ; Viallon, Vivian


Background: The "meeting-in-the-middle" (Nirmt) is a principle to identify exposure biornarkers that are also predictors of disease. The MITM statistical framework was applied in a nested case-control study of hepatocellular carcinoma (HCC) within European Prospective Investigation into Cancer and Nutrition (EPIC), where healthy lifestyle index (I-ILO variables were related to targeted serum ...


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