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Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors

Sellmer, Andreas ; Stangl, Hubert ; Beyer, Mandy ; Grünstein, Elisabeth ; Leonhardt, Michel ; Pongratz, Herwig ; Eichhorn, Emerich ; Elz, Sigurd ; Striegl, Birgit ; Jenei-Lanzl, Zsuzsa ; Dove, Stefan ; Straub, Rainer H. ; Krämer, Oliver H. ; Mahboobi, Siavosh


Epigenetic modifiers of the histone deacetylase (HDAC) family contribute to autoimmunity, cancer, HIV infection, inflammation, and neurodegeneration. Hence, histone deacetylase inhibitors (HDACi), which alter protein acetylation, gene expression patterns, and cell fate decisions, represent promising new drugs for the therapy of these diseases. Whereas pan-HDACi inhibit all 11 Zn2+-dependent ...


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