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Interactions, localization, and phosphorylation of the m6A generating METTL3–METTL14–WTAP complex

Schöller, Eva ; Weichmann, Franziska ; Treiber, Thomas ; Ringle, Sam ; Treiber, Nora ; Flatley, Andrew ; Feederle, Regina ; Bruckmann, Astrid ; Meister, Gunter


N-6-methyladenine (m(6)A) is found on many eukaryotic RNAs including mRNAs. m(6)A modification has been implicated in mRNA stability and turnover, localization, or translation efficiency. A heterodimeric enzyme complex composed of METTL3 and METTL14 generates m(6)A on mRNAs. METTL3/14 is found in the nucleus where it is localized to nuclear speckles and the splicing regulator WTAP is required for ...


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