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Sulfate derivatives of 2-phenylindoles as novel steroid sulfatase inhibitors. An in vitro study on structure-activity-relationship

Birnböck, H. ; Angerer, E. von



Abstract

The growth of hormone-dependent mammary tumor cells is stimulated by non-conjugated estrogens. One important source of these hormones in the tumors could be the enzymatic hydrolysis of circulating estrogen sulfates by steroid sulfatase (EC 3.1.6.2). Inhibition of this enzyme may result in reduced levels of endogenous estrogens and, consequently, in a reduced proliferation rate of ...

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