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Structural basis for the interaction between the cell polarity proteins Par3 and Par6

Renschler, Fabian A. ; Bruekner, Susanne R. ; Salomon, Paulin L. ; Mukherjee, Amrita ; Kullmann, Lars ; Schütz-Stoffregen, Mira C. ; Henzler, Christine ; Pawson, Tony ; Krahn, Michael P. ; Wiesner, Silke


Polarity is a fundamental property of most cell types. The Par protein complex is a major driving force in generating asymmetrically localized protein networks and consists of atypical protein kinase C (aPKC), Par3, and Par6. Dysfunction of this complex causes developmental abnormalities and diseases such as cancer. We identified a PDZ domain-binding motif in Par6 that was essential for its ...


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