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A rapid luciferase transfection assay for transcription activation effects and stability control of estrogenic drugs in cell cultures

Meyer, T., Koop, R., Angerer, E. von, Schönenberger, H. and Holler, E. (1994) A rapid luciferase transfection assay for transcription activation effects and stability control of estrogenic drugs in cell cultures. Journal of Cancer Research and Clinical Oncology 120 (6), pp. 359-364.

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Abstract

A rapid assay system for measuring the potential of estrogenic drugs is introduced. Luciferase induction could be measured in estrogen-receptor-positive human MCF-7 breast cancer cells, which had been transfected with a novel luciferase reporter plasmid ERE luc. The minimal requirement was 1 h exposure to the inducing drug and 3.5 h of incubation after removal of the drug. The assay system was ...

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Item type:Article
Date:1994
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/3
Identification Number:
ValueType
8138561PubMed ID
Classification:
NotationType
Antineoplastic Agents/pharmacologyMESH
Breast Neoplasms/metabolismMESH
Enzyme Activation/drug effectsMESH
Estradiol/pharmacologyMESH
Estrogens, Non-Steroidal/pharmacologyMESH
FemaleMESH
HumansMESH
Luciferases/geneticsMESH
Organoplatinum Compounds/pharmacologyMESH
Receptors, Estrogen/drug effectsMESH
Transcription, Genetic/drug effectsMESH
TransfectionMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:4763
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