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1-Carbamoylalkyl-2-phenylindoles: relationship between side chain structure and estrogen antagonism

Angerer, E. von ; Biberger, C. ; Holler, E. ; Koop, R. ; Leichtl, S.



Abstract

The 2-phenylindole system has proved to be a versatile structure for the design of potent antiestrogens, especially when functional groups have been introduced into the alkyl side chain in position 1. In analogy to steroidal structures such as ICI 164,384 a number of 2-phenylindoles with carbamoylalkyl and aminoalkyl side chains were synthesized. They bind to the calf uterine estrogen receptor ...

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