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Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells

Walter, Georg, Liebl, Renate and Angerer, Erwin von (2004) Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells. Archiv der Pharmazie 337 (12), pp. 634-644.

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Estrone sulfate (E1S) is an endogenous prodrug that delivers estrone and, subsequently, estradiol to target cells, after hydrolysis by the enzyme estrone sulfatase, which is active in various tissues including hormone-dependent breast cancer. Blockade of this enzyme should reduce the estrogen level in breast cancer cells and prevent hormonal growth stimulation. In this study, a number of ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:DFG Projekt An 139/6
Identification Number:
15597397PubMed ID
Breast Neoplasms/enzymologyMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
Enzyme Inhibitors/chemical synthesisMESH
Estrogen Receptor Modulators/chemical synthesisMESH
Molecular StructureMESH
Protein BindingMESH
Radioligand AssayMESH
Receptors, Estrogen/metabolismMESH
Stilbenes/chemical synthesisMESH
Structure-Activity RelationshipMESH
Sulfatases/antagonists & inhibitorsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:4779
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