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Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells

Kaufmann, Doris, Pojarová, Michaela, Vogel, Susanne, Liebl, Renate, Gastpar, Robert, Gross, Dietmar, Nishino, Tsuyuki, Pfaller, Tobias and Angerer, Erwin von (2007) Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells. Bioorganic & medicinal chemistry 15 (15), pp. 5122-36.

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Abstract

Small molecules such as indoles are attractive as inhibitors of tubulin polymerization. Thus a number of 2-phenylindole-3-carbaldehydes with lipophilic substituents in both aromatic rings was synthesized and evaluated for antitumor activity in MDA-MB 231 and MCF-7 breast cancer cells. Some 5-alkylindole derivatives with a 4-methoxy group in the 2-phenyl ring strongly inhibit the growth of breast ...

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Item type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
17533132PubMed ID
10.1016/j.bmc.2007.05.030DOI
Classification:
NotationType
Aldehydes/chemistryMESH
Antineoplastic Agents/chemistryMESH
Breast Neoplasms/drug therapyMESH
Cell Line, TumorMESH
Cell Proliferation/drug effectsMESH
Cell Shape/drug effectsMESH
Cells/drug effectsMESH
HumansMESH
Mitosis/drug effectsMESH
Molecular StructureMESH
Structure-Activity RelationshipMESH
Time FactorsMESH
Tubulin/metabolismMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:4784
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