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Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells

Kaufmann, Doris ; Pojarová, Michaela ; Vogel, Susanne ; Liebl, Renate ; Gastpar, Robert ; Gross, Dietmar ; Nishino, Tsuyuki ; Pfaller, Tobias ; Angerer, Erwin von



Abstract

Small molecules such as indoles are attractive as inhibitors of tubulin polymerization. Thus a number of 2-phenylindole-3-carbaldehydes with lipophilic substituents in both aromatic rings was synthesized and evaluated for antitumor activity in MDA-MB 231 and MCF-7 breast cancer cells. Some 5-alkylindole derivatives with a 4-methoxy group in the 2-phenyl ring strongly inhibit the growth of breast ...

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