Platinum(II) complexes interfering with testicular steroid biosynthesis: drugs for the therapy of advanced or recurrent prostate cancers? Preclinical studies

Schertl, Sabine, Hartmann, Rolf W., Batzl-Hartmann, Christine, Spruss, Thilo, Maucher, Anton, Angerer, Erwin von, Schiller, Claus D., Schneider, Martin R., Gust, Ronald and Schönenberger, Helmut (2007) Platinum(II) complexes interfering with testicular steroid biosynthesis: drugs for the therapy of advanced or recurrent prostate cancers? Preclinical studies. Journal of Cancer Research and Clinical Oncology 133 (3), pp. 153-167.

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Abstract

[Meso-1,2-bis(2,6-dihalo-3/4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-1-PtLL': 2,6-F(2),3-OH; meso-2-PtLL': 2,6-F(2),4-OH; meso-3-PtLL': 2,6-Cl(2),3-OH; meso-4-PtLL': 2,6-Cl(2),4-OH; L = OH(2), L' = OSO(3) or L,L' = Cl(2)) were designed with the aim to get drugs comprising both cytotoxic and testosterone level lowering potencies. It is assumed that such compounds are more ...

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