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Platinum(II) complexes interfering with testicular steroid biosynthesis: drugs for the therapy of advanced or recurrent prostate cancers? Preclinical studies

Schertl, Sabine ; Hartmann, Rolf W. ; Batzl-Hartmann, Christine ; Spruss, Thilo ; Maucher, Anton ; Angerer, Erwin von ; Schiller, Claus D. ; Schneider, Martin R. ; Gust, Ronald ; Schönenberger, Helmut



Abstract

[Meso-1,2-bis(2,6-dihalo-3/4-hydroxyphenyl)ethylenediamine]platinum(II) complexes (meso-1-PtLL': 2,6-F(2),3-OH; meso-2-PtLL': 2,6-F(2),4-OH; meso-3-PtLL': 2,6-Cl(2),3-OH; meso-4-PtLL': 2,6-Cl(2),4-OH; L = OH(2), L' = OSO(3) or L,L' = Cl(2)) were designed with the aim to get drugs comprising both cytotoxic and testosterone level lowering potencies. It is assumed that such compounds are more ...

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