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Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents

Vogel, Susanne ; Kaufmann, Doris ; Pojarová, Michaela ; Müller, Christine ; Pfaller, Tobias ; Kühne, Sybille ; Bednarski, Patrick J ; Angerer, Erwin von


Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of various benzoic and pyridine carboxylic acids. The resulting hydrazones inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC(50) values of 20-30 nM for the most potent ...


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