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[meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] sulfatoplatinum(II)--pharmacokinetic studies

Bernhardt, Günther ; Koch, Marion ; Spruss, Thilo ; Gust, Ronald ; Krauser, Rudolf ; Schlemmer, Richard ; Hollstein, Michael ; Lux, Franz ; Schönenberger, Helmut



Abstract

The maximally attainable level of the non-plasma protein bound fraction of a single 10.0 mumol/kg i.p. dose of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] sulfatoplatinum(II), a drug active on the murine, hormone-sensitive MXT-M-3.2 breast cancer, lies markedly below the concentration causing a significant cytotoxic effect on a cell line derived from this tumor. This result ...

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