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[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - mode of action II: contribution of drug inactivation, cellular drug uptake and sterical factors in the drug-target interaction to the antitumor activity

Schertl, Sabine ; Hartmann, Rolf W. ; Batzl-Hartmann, Christine ; Bernhardt, Günther ; Spruss, Thilo ; Beckenlehner, Karin ; Koch, Marion ; Krauser, Rudolf ; Schlemmer, Richard ; Gust, Ronald ; Schönenberger, Helmut



Abstract

The marked activity of [meso-1, 2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II) (meso-3-PtLL', L, L' = Cl(2) or L = OH(2), L' = OSO(3)) on the hormone-sensitive MXT-M-3, 2 breast cancer implanted in mice is most probably due to a mechanism based on the reduction of the endogenous estrogen level. Cytotoxic effects which are poorly pronounced in experiments on several breast cancer ...

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