Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloro-platinum(II) act as an immune response modifier? Part III: Progressively growing MXT-M-3,2 breast cancer stimulates the proliferation of phagocytes in B6D2F1 mice

Schlemmer, Richard ; Spruß, Thilo ; Bernhardt, Günther ; Schönenberger, Helmut

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Details

Item type:	Article
Journal or Publication Title:	Archiv der Pharmazie
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
Volume:	333
Number of Issue or Book Chapter:	12
Page Range:	pp. 404-414
Date:	2000
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects (Historical):	SFB 234
Identification Number:	Value Type 11199470 PubMed ID 10.1002/1521-4184(200012)333:12<404::AID-ARDP404>3.0.CO;2-M DOI
Classification:	Notation Type Animals MESH Antineoplastic Agents/pharmacology MESH Breast Neoplasms/drug therapy MESH Cell Division/drug effects MESH Female MESH Humans MESH Immunity, Cellular/drug effects MESH Immunologic Factors/pharmacology MESH Mice MESH Mice, Inbred Strains MESH Organoplatinum Compounds/pharmacology MESH Phagocytes/drug effects MESH Transplantation, Heterologous MESH Tumor Cells, Cultured MESH
Keywords:	TUMOR-BEARING MICE; MACROPHAGE-MEDIATED CYTOTOXICITY; MONOCLONAL-ANTIBODY GK1.5; OXIDE SYNTHASE GENE; BONE-MARROW CELLS; MAMMARY-TUMOR; PHOSPHATIDYL SERINE; SUPPRESSOR CELLS; NK CELLS; GRANULOCYTE; murine MXT-M-3,2 breast cancer; phagocyte proliferation; tumor-host-interaction; flow cytometry
Dewey Decimal Classification:	600 Technology > 615 Pharmacy 500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	4839

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Abstract

MXT-M-3,2 breast cancer implanted into female B6D2F(1) mice accelerates the growth of an identical second tumor. This process is accompanied by a significant increase of the granulocyte and monocyte numbers in the blood and of the granulocyte and macrophage numbers in the spleen. A significant positive correlation of strong intensity was found between the tumor weight on the one hand and the ...

Abstract

MXT-M-3,2 breast cancer implanted into female B6D2F(1) mice accelerates the growth of an identical second tumor. This process is accompanied by a significant increase of the granulocyte and monocyte numbers in the blood and of the granulocyte and macrophage numbers in the spleen. A significant positive correlation of strong intensity was found between the tumor weight on the one hand and the number of the granulocytes and macrophages on the other hand. The tumor-dependent promotion of the myelopoiesis is explained with a secretion of hematopoietic growth factors, e.g. of the,granulocyte-macrophage-stimulating growth factor (GMCSF), by the breast cancer cells.

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Metadata last modified: 29 Sep 2021 07:28

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