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RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas

Wirthschaft, Peter ; Bode, Julia ; Soni, Himanshu ; Dietrich, Fabio ; Krüwel, Thomas ; Fischer, Bernd ; Knobbe-Thomsen, Christiane B. ; Rossetti, Giulia ; Hentschel, Andreas ; Mack, Norman ; Schönig, Kai ; Breckwoldt, Michael O. ; Schmandke, André ; Pusch, Stefan ; Medenbach, Jan ; Bendszus, Martin ; Schwab, Martin E. ; von Deimling, Andreas ; Kool, Marcel ; Herold-Mende, Christel ; Reifenberger, Guido ; Ahrends, Robert ; Tews, Björn


Glioblastomas strongly invade the brain by infiltrating into the white matter along myelinated nerve fiber tracts even though the myelin protein Nogo-A prevents cell migration by activating inhibitory RhoA signaling. The mechanisms behind this long-known phenomenon remained elusive so far, precluding a targeted therapeutic intervention. This study demonstrates that the prevalent activation of AKT ...


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