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Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase

Semmelmann, Florian ; Straub, Kristina ; Nazet, Julian ; Rajendran, Chitra ; Merkl, Rainer ; Sterner, Reinhard


Allosteric communication between different subunits in metabolic enzyme complexes is of utmost physiological importance but only understood for few systems. We analyzed the structural basis of allostery in aminodeoxychorismate synthase (ADCS), which is a member of the family of glutamine amidotransferases and catalyzes the committed step of the folate biosynthetic pathway. ADCS consists of the ...


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