; Sim, Xueling ; Vojinovic, Dina
; Huffman, Jennifer E. ; Musani, Solomon K. ; Li, Changwei
; Feitosa, Mary F.
; Richard, Melissa A. ; Noordam, Raymond ; Aschard, Hugues ; Bartz, Traci M. ; Bielak, Lawrence F. ; Deng, Xuan ; Dorajoo, Rajkumar ; Lohman, Kurt K. ; Manning, Alisa K. ; Rankinen, Tuomo ; Smith, Albert V.
; Tajuddin, Salman M.
; Evangelou, Evangelos ; Graff, Mariaelisa ; Alver, Maris ; Boissel, Mathilde
; Chai, Jin Fang ; Chen, Xu
; Divers, Jasmin ; Gandin, Ilaria ; Gao, Chuan ; Goel, Anuj
; Hagemeijer, Yanick
; Harris, Sarah E. ; Hartwig, Fernando P. ; He, Meian ; Horimoto, Andrea R. V. R. ; Hsu, Fang-Chi ; Jackson, Anne U. ; Kasturiratne, Anuradhani ; Komulainen, Pirjo ; Kühnel, Brigitte ; Laguzzi, Federica ; Lee, Joseph H. ; Luan, Jian'an ; Lyytikäinen, Leo-Pekka ; Matoba, Nana
; Nolte, Ilja M. ; Pietzner, Maik ; Riaz, Muhammad
; Said, M Abdullah
; Scott, Robert A. ; Sofer, Tamar
; Stančáková, Alena ; Takeuchi, Fumihiko ; Tayo, Bamidele O. ; van der Most, Peter J. ; Varga, Tibor V.
; Wang, Yajuan ; Ware, Erin B. ; Wen, Wanqing ; Yanek, Lisa R. ; Zhang, Weihua ; Zhao, Jing Hua ; Afaq, Saima ; Amin, Najaf ; Amini, Marzyeh ; Arking, Dan E. ; Aung, Tin ; Ballantyne, Christie ; Boerwinkle, Eric ; Broeckel, Ulrich ; Campbell, Archie ; Canouil, Mickaël
; Charumathi, Sabanayagam ; Chen, Yii-Der Ida
; Connell, John M. ; de Faire, Ulf ; de las Fuentes, Lisa
; de Mutsert, Renée ; de Silva, H. Janaka ; Ding, Jingzhong ; Dominiczak, Anna F. ; Duan, Qing ; Eaton, Charles B. ; Eppinga, Ruben N. ; Faul, Jessica D. ; Fisher, Virginia ; Forrester, Terrence ; Franco, Oscar H. ; Friedlander, Yechiel ; Ghanbari, Mohsen ; Giulianini, Franco ; Grabe, Hans J. ; Grove, Megan L. ; Gu, C. Charles ; Harris, Tamara B. ; Heikkinen, Sami
; Heng, Chew-Kiat ; Hirata, Makoto ; Hixson, James E. ; Howard, Barbara V. ; Ikram, M. Arfan ; Jacobs, David R. ; Johnson, Craig ; Jonas, Jost Bruno ; Kammerer, Candace M.
; Katsuya, Tomohiro ; Khor, Chiea Chuen ; Kilpeläinen, Tuomas O.
; Koh, Woon-Puay ; Koistinen, Heikki A. ; Kolcic, Ivana ; Kooperberg, Charles ; Krieger, Jose E. ; Kritchevsky, Steve B. ; Kubo, Michiaki ; Kuusisto, Johanna ; Lakka, Timo A. ; Langefeld, Carl D. ; Langenberg, Claudia ; Launer, Lenore J. ; Lehne, Benjamin ; Lemaitre, Rozenn N. ; Li, Yize
; Liang, Jingjing ; Liu, Jianjun
; Liu, Kiang
; Loh, Marie ; Louie, Tin ; Mägi, Reedik ; Manichaikul, Ani W. ; McKenzie, Colin A. ; Meitinger, Thomas ; Metspalu, Andres ; Milaneschi, Yuri ; Milani, Lili ; Mohlke, Karen L. ; Mosley, Thomas H. ; Mukamal, Kenneth J. ; Nalls, Mike A. ; Nauck, Matthias ; Nelson, Christopher P. ; Sotoodehnia, Nona ; O'Connell, Jeff R. ; Palmer, Nicholette D. ; Pazoki, Raha ; Pedersen, Nancy L. ; Peters, Annette ; Peyser, Patricia A. ; Polasek, Ozren
; Poulter, Neil ; Raffel, Leslie J. ; Raitakari, Olli T. ; Reiner, Alex P. ; Rice, Treva K. ; Rich, Stephen S. ; Robino, Antonietta ; Robinson, Jennifer G. ; Rose, Lynda M. ; Rudan, Igor ; Schmidt, Carsten O. ; Schreiner, Pamela J. ; Scott, William R. ; Sever, Peter ; Shi, Yuan ; Sidney, Stephen ; Sims, Mario ; Smith, Blair H.
; Smith, Jennifer A.
; Snieder, Harold ; Starr, John M. ; Strauch, Konstantin ; Tan, Nicholas ; Taylor, Kent D. ; Teo, Yik Ying ; Tham, Yih Chung ; Uitterlinden, André G. ; van Heemst, Diana ; Vuckovic, Dragana ; Waldenberger, Melanie
; Wang, Lihua ; Wang, Yujie ; Wang, Zhe ; Wei, Wen Bin ; Williams, Christine ; Wilson, Gregory ; Wojczynski, Mary K. ; Yao, Jie ; Yu, Bing ; Yu, Caizheng ; Yuan, Jian-Min ; Zhao, Wei ; Zonderman, Alan B. ; Becker, Diane M. ; Boehnke, Michael ; Bowden, Donald W. ; Chambers, John C. ; Deary, Ian J. ; Esko, Tõnu ; Farrall, Martin ; Franks, Paul W. ; Freedman, Barry I. ; Froguel, Philippe ; Gasparini, Paolo ; Gieger, Christian ; Horta, Bernardo L. ; Kamatani, Yoichiro ; Kato, Norihiro ; Kooner, Jaspal S. ; Laakso, Markku ; Leander, Karin
; Lehtimäki, Terho ; Magnusson, Patrik K. E. ; Penninx, Brenda ; Pereira, Alexandre C. ; Rauramaa, Rainer ; Samani, Nilesh J. ; Scott, James ; Shu, Xiao-Ou ; van der Harst, Pim ; Wagenknecht, Lynne E. ; Wang, Ya Xing ; Wareham, Nicholas J. ; Watkins, Hugh ; Weir, David R. ; Wickremasinghe, Ananda R. ; Zheng, Wei ; Elliott, Paul ; North, Kari E. ; Bouchard, Claude
; Evans, Michele K. ; Gudnason, Vilmundur
; Liu, Ching-Ti
; Liu, Yongmei
; Psaty, Bruce M. ; Ridker, Paul M. ; van Dam, Rob M.
; Kardia, Sharon L. R. ; Zhu, Xiaofeng
; Rotimi, Charles N. ; Mook-Kanamori, Dennis O. ; Fornage, Myriam ; Kelly, Tanika N. ; Fox, Ervin R. ; Hayward, Caroline ; van Duijn, Cornelia M. ; Tai, E. Shyong ; Wong, Tien Yin ; Liu, Jingmin
; Rotter, Jerome I. ; Gauderman, W. James ; Province, Michael A. ; Munroe, Patricia B. ; Rice, Kenneth ; Chasman, Daniel I. ; Cupples, L. Adrienne ; Rao, Dabeeru C. ; Morrison, Alanna C. | Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | American Journal of Epidemiology | ||||
| Verlag: | Oxford Univ. Press | ||||
| Ort der Veröffentlichung: | CARY | ||||
| Band: | 188 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 6 | ||||
| Seitenbereich: | S. 1033-1054 | ||||
| Datum: | 2019 | ||||
| Institutionen: | Medizin > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-HEART-DISEASE; HDL CHOLESTEROL; LOW-FREQUENCY; BLOOD-LIPIDS; VEGF-B; METAANALYSIS; PLASMA; CONSUMPTION; INDIVIDUALS; alcohol consumption; cholesterol; gene-environment interactions; gene-lifestyle interactions; genome-wide association studies; lipids; triglycerides | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 48591 |
Zusammenfassung
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies ...

Zusammenfassung
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
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