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Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion

Dickerson, Matthew T. ; Dadi, Prasanna K. ; Altman, Molly K. ; Verlage, Kenneth R. ; Thorson, Ariel S. ; Jordan, Kelli L. ; Vierra, Nicholas C. ; Amarnath, Gautami ; Jacobson, David A.



Abstract

Pancreatic alpha-cells exhibit oscillations in cytosolic Ca2+ (Ca-c(2+)), which control pulsatile glucagon (GCG) secretion. However, the mechanisms that modulate alpha-cell Ca-c(2+) oscillations have not been elucidated. As beta-cell Ca-c(2-) oscillations are regulated in part by Ca2+-activated K+(K-SLOW) currents, this work investigated the role of K-SLOW, in alpha-cell Ca(2+ )handling and GCG ...

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