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Use of metformin and survival of patients with high-grade glioma

Seliger, Corinna ; Luber, Christian ; Gerken, Michael ; Schaertl, Julia ; Proescholdt, Martin ; Riemenschneider, Markus J. ; Meier, Christoph R. ; Bogdahn, Ulrich ; Leitzmann, Michael F. ; Klinkhammer-Schalke, Monika ; Hau, Peter


High-grade glioma (HGG) is associated with poor prognosis. Drug repurposing evolves as new modality to improve standard therapy. The antidiabetic drug metformin has been found to inhibit glioma cell growth in vitro and in vivo. The aim of the present retrospective cohort study was to evaluate the survival of patients with HGG with or without treatment with metformin, based on a large cohort of a ...


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