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Functional characterization of Regulator of Cyclin A1 (Rca1) as an APC/C substrate and inhibitor

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Polz, Jan
Date of publication of this fulltext: 25 Jul 2022 07:40

Abstract (English)

The cell division cycle is regulated by the timely degradation of cell cycle regulators leading to an abrupt and irreversible change of protein concentration. At the centre of this system are E3 ubiquitin ligases that mark substrates for degradation by the 26S proteasome at precise time points during cell cycle progression. The anaphase promoting complex or cyclosome (APC/C) is a multi-subunit E3 ...


Translation of the abstract (German)

Der durch E3 -Ubiquitin -Ligasen vermittelte proteolytische Abbau von Proteinen zu genau definierten Zeitpunkten ist ein zentraler Bestandteil der Regulation des Zellzyklus. Der APC/C-Komplex (Anaphase-Promoting-Complex/Cyclosome) ist verantwortlich für den strikt geregelten Abbau einer Vielfalt von regulatorischen Proteinen während der Mitose und der G1-Phase. Eine Inaktivierung des APC/C in der ...


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