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Splicing Endonuclease Is an Important Player in rRNA and tRNA Maturation in Archaea

Schwarz, Thandi S. ; Berkemer, Sarah J. ; Bernhart, Stephan H. ; Weiß, Matthias ; Ferreira-Cerca, Sébastien ; Stadler, Peter F. ; Marchfelder, Anita


In all three domains of life, tRNA genes contain introns that must be removed to yield functional tRNA. In archaea and eukarya, the first step of this process is catalyzed by a splicing endonuclease. The consensus structure recognized by the splicing endonuclease is a bulge-helix-bulge (BHB) motif which is also found in rRNA precursors. So far, a systematic analysis to identify all biological ...


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