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Reliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio

URN to cite this document:
urn:nbn:de:bvb:355-epub-500898
DOI to cite this document:
10.5283/epub.50089
Buchert, Ralph ; Dirks, Meike ; Schütze, Christian ; Wilke, Florian ; Mamach, Martin ; Wirries, Ann-Katrin ; Pflugrad, Henning ; Hamann, Linda ; Langer, Laura B.N. ; Wetzel, Christian ; Lukacevic, Mario ; Polyak, Andras ; Kessler, Mariella ; Petrusch, Carlotta ; Bengel, Frank M. ; Geworski, Lilli ; Rupprecht, Rainer ; Weissenborn, Karin ; Ross, Tobias L. ; Berding, Georg
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 11 Oct 2021 12:51



Abstract

Purpose Tracer kinetic modeling of tissue time activity curves and the individual input function based on arterial blood sampling and metabolite correction is the gold standard for quantitative characterization of microglia activation by PET with the translocator protein (TSPO) ligand F-18-GE-180. This study tested simplified methods for quantification of F-18-GE-180 PET. Methods Dynamic ...

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