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Reliable quantification of 18F-GE-180 PET neuroinflammation studies using an individually scaled population-based input function or late tissue-to-blood ratio

Buchert, Ralph ; Dirks, Meike ; Schütze, Christian ; Wilke, Florian ; Mamach, Martin ; Wirries, Ann-Katrin ; Pflugrad, Henning ; Hamann, Linda ; Langer, Laura B.N. ; Wetzel, Christian ; Lukacevic, Mario ; Polyak, Andras ; Kessler, Mariella ; Petrusch, Carlotta ; Bengel, Frank M. ; Geworski, Lilli ; Rupprecht, Rainer ; Weissenborn, Karin ; Ross, Tobias L. ; Berding, Georg


Purpose Tracer kinetic modeling of tissue time activity curves and the individual input function based on arterial blood sampling and metabolite correction is the gold standard for quantitative characterization of microglia activation by PET with the translocator protein (TSPO) ligand F-18-GE-180. This study tested simplified methods for quantification of F-18-GE-180 PET. Methods Dynamic ...


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