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miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells

Lim, Clarice X. ; Lee, Bernett ; Geiger, Olivia ; Passegger, Christina ; Beitzinger, Michaela ; Romberger, Johann ; Stracke, Anika ; Högenauer, Christoph ; Stift, Anton ; Stoiber, Heribert ; Poidinger, Michael ; Zebisch, Armin ; Meister, Gunter ; Williams, Adam ; Flavell, Richard A. ; Henao-Mejia, Jorge ; Strobl, Herbert


DC-SIGN(+) monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a microRNA, miR-181a, and a molecular mechanism that simultaneously regulate the acquisition of DC-SIGN expression and the activation state of DC-SIGN(+) ...


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