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Fluorescence Labeling of Neurotensin(8–13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity

Keller, Max ; Mahuroof, Shahani A. ; Hong Yee, Vivyanne ; Carpenter, Jessica ; Schindler, Lisa ; Littmann, Timo ; Pegoli, Andrea ; Hübner, Harald ; Bernhardt, Günther ; Gmeiner, Peter ; Holliday, Nicholas D.



Abstract

Fluorescence-labeled receptor ligands have emerged as valuable molecular tools, being indispensable for studying receptor-ligand interactions by fluorescence-based techniques such as high-content imaging, fluorescence microscopy, and fluorescence polarization. Through application of a new labeling strategy for peptides, a series of fluorescent neurotensin(8-13) derivatives was synthesized by ...

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