Metamizole but not ibuprofen reduces the plasma concentration of sertraline: Implications for the concurrent treatment of pain and depression/anxiety disorders

URN to cite this document:: urn:nbn:de:bvb:355-epub-506508
DOI to cite this document:: 10.5283/epub.50650

Gaebler, Arnim Johannes

; Schoretsanitis, Georgios ; Ben Omar, Nagia ; Haen, Ekkehard ; Endres, Katharina ; Hiemke, Christoph ; Paulzen, Michael

License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 11 Oct 2021 13:10

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Abstract

Aim Comorbidity of pain and depression or anxiety is a challenging clinical phenomenon, often requiring the concurrent application of antidepressant and analgesic drugs. Growing evidence suggests that the analgesic metamizole exhibits cytochrome P450 inducing properties. In the present study, we assessed the impact of metamizole and ibuprofen on plasma concentrations of the selective serotonin ...