Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone

URN to cite this document:: urn:nbn:de:bvb:355-epub-510271
DOI to cite this document:: 10.5283/epub.51027

Siska, Peter J. ; Decking, Sonja-Maria ; Babl, Nathalie ; Matos, Carina ; Bruss, Christina ; Singer, Katrin ; Klitzke, Jana ; Schön, Marian ; Simeth, Jakob

; Köstler, Josef ; Siegmund, Heiko ; Ugele, Ines ; Paulus, Michael ; Dietl, Alexander ; Kolodova, Kristina ; Steines, Louisa

; Freitag, Katharina ; Peuker, Alice ; Schönhammer, Gabriele ; Raithel, Johanna ; Graf, Bernhard ; Geismann, Florian ; Lubnow, Matthias ; Mack, Matthias ; Hau, Peter ; Bohr, Christopher ; Burkhardt, Ralph

; Gessner, Andre ; Salzberger, Bernd ; Wagner, Ralf ; Hanses, Frank ; Hitzenbichler, Florian ; Heudobler, Daniel ; Lüke, Florian ; Pukrop, Tobias ; Herr, Wolfgang ; Wolff, Daniel ; Spang, Rainer ; Poeck, Hendrik ; Hoffmann, Petra ; Jantsch, Jonathan ; Brochhausen, Christoph ; Lunz, Dirk ; Rehli, Michael ; Kreutz, Marina ; Renner, Kathrin

Date of publication of this fulltext: 01 Dec 2021 06:00

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Abstract

Metabolic pathways regulate immune responses and disrupted metabolism leads to immune dysfunction and disease. Coronavirus disease 2019 (COVID-19) is driven by imbalanced immune responses, yet the role of immunometabolism in COVID-19 pathogenesis remains unclear. By investigating 87 patients with confirmed SARS-CoV-2 infection, 6 critically ill non-COVID-19 patients, and 47 uninfected controls, ...