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Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs

Schöller, Eva ; Marks, James ; Marchand, Virginie ; Bruckmann, Astrid ; Powell, Christopher A. ; Reichold, Markus ; Mutti, Christian Daniel ; Dettmer, Katja ; Feederle, Regina ; Hüttelmaier, Stefan ; Helm, Mark ; Oefner, Peter J. ; Minczuk, Michal ; Motorin, Yuri ; Hafner, Markus ; Meister, Gunter



Abstract

Mitochondria contain a specific translation machinery for the synthesis of mitochondria-encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs) are also generated from the mitochondrial DNA and, similar to their cytoplasmic counterparts, are post-transcriptionally modified. Here, we find that the RNA methyltransferase METTL8 is a mitochondrial protein that facilitates ...

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