| Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (4MB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-513986
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.51398
Zusammenfassung
G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with alpha subunits of distinct G protein families, they regulate cellular responses. The histamine H-2 and H-4 receptors (H2R and H4R) are prominent members of Gs- and Gi-coupled GPCRs. Nevertheless, promiscuous G ...
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