Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex

URN to cite this document:: urn:nbn:de:bvb:355-epub-517162
DOI to cite this document:: 10.5283/epub.51716

Wurm, Jan Philip

; Sung, Sihyun

; Kneuttinger, Andrea Christa ; Hupfeld, Enrico ; Sterner, Reinhard

; Wilmanns, Matthias

; Sprangers, Remco

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Date of publication of this fulltext: 17 Feb 2022 14:46

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Abstract

Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is responsible for the HisH-catalyzed hydrolysis of glutamine to glutamate and ammonia, which is then used for a cyclase reaction by HisF. The HisFH complex is allosterically regulated but the underlying mechanism is not well understood. Here, we elucidate the ...