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Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex

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Wurm, Jan Philip ; Sung, Sihyun ; Kneuttinger, Andrea Christa ; Hupfeld, Enrico ; Sterner, Reinhard ; Wilmanns, Matthias ; Sprangers, Remco
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Feb 2022 14:46


Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is responsible for the HisH-catalyzed hydrolysis of glutamine to glutamate and ammonia, which is then used for a cyclase reaction by HisF. The HisFH complex is allosterically regulated but the underlying mechanism is not well understood. Here, we elucidate the ...


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