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Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections

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Neumann, Bernhard ; Angstwurm, Klemens ; Linker, Ralf A. ; Knoll, Gertrud ; Eidenschink, Lisa ; Rubbenstroth, Dennis ; Schlottau, Kore ; Beer, Martin ; Schreiner, Patrick ; Soutschek, Erwin ; Böhmer, Merle M. ; Lampl, Benedikt M.J. ; Pregler, Matthias ; Scheiter, Alexander ; Evert, Katja ; Zoubaa, Saida ; Riemenschneider, Markus J. ; Asbach, Benedikt ; Gessner, André ; Niller, Hans Helmut ; Schmidt, Barbara ; Bauswein, Markus
Date of publication of this fulltext: 28 Mar 2022 09:19


Borna disease virus 1 (BoDV-1) causes rare but often fatal encephalitis in humans. Late diagnosis prohibits an experimental therapeutic approach. Here, we report a recent case of fatal BoDV-1 infection diagnosed on day 12 after hospitalization by detection of BoDV-1 RNA in the cerebrospinal fluid. In a retrospective analysis, we detect BoDV-1 RNA 1 day after hospital admission when the cell count ...


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