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Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity

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Frick, Linus ; Hinterland, Linda ; Renner, Kathrin ; Vogl, Marion ; Babl, Nathalie ; Heckscher, Simon ; Weigert, Anna ; Weiß, Susanne ; Gläsner, Joachim ; Berger, Raffaela ; Oefner, Peter J. ; Dettmer, Katja ; Kreutz, Marina ; Schatz, Valentin ; Jantsch, Jonathan
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 24 Mar 2022 16:33


Local tissue acidosis affects anti-tumor immunity. In contrast, data on tissue pH levels in infected tissues and their impact on antimicrobial activity is sparse. In this study, we assessed the pH levels in cutaneous Leishmania lesions. Leishmania major-infected skin tissue displayed pH levels of 6.7 indicating that lesional pH is acidic. Next, we tested the effect of low extracellular pH on the ...


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