Go to content
UR Home

Acidic Microenvironments Found in Cutaneous Leishmania Lesions Curtail NO-Dependent Antiparasitic Macrophage Activity

URN to cite this document:
urn:nbn:de:bvb:355-epub-519874
DOI to cite this document:
10.5283/epub.51987
Frick, Linus ; Hinterland, Linda ; Renner, Kathrin ; Vogl, Marion ; Babl, Nathalie ; Heckscher, Simon ; Weigert, Anna ; Weiß, Susanne ; Gläsner, Joachim ; Berger, Raffaela ; Oefner, Peter J. ; Dettmer, Katja ; Kreutz, Marina ; Schatz, Valentin ; Jantsch, Jonathan
[img]
Preview
License: Creative Commons Attribution 4.0
PDF - Published Version
(2MB)
Date of publication of this fulltext: 24 Mar 2022 16:33


Abstract

Local tissue acidosis affects anti-tumor immunity. In contrast, data on tissue pH levels in infected tissues and their impact on antimicrobial activity is sparse. In this study, we assessed the pH levels in cutaneous Leishmania lesions. Leishmania major-infected skin tissue displayed pH levels of 6.7 indicating that lesional pH is acidic. Next, we tested the effect of low extracellular pH on the ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 4239

Dissertations: dissertationen@ur.de
0941 943 3904

Research data: daten@ur.de
0941 943 4239

Contact persons