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Empagliflozin Reduces Renal Hyperfiltration in Response to Uninephrectomy, but Is Not Nephroprotective in UNx/DOCA/Salt Mouse Models

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Tauber, Philipp ; Sinha, Frederick ; Berger, Raffaela S. ; Gronwald, Wolfram ; Dettmer, Katja ; Kuhn, Michaela ; Trum, Maximilian ; Maier, Lars S. ; Wagner, Stefan ; Schweda, Frank
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 07 Apr 2022 04:53


Large-scale clinical outcome studies demonstrated the efficacy of SGLT2 inhibitors in patients with type II diabetes. Besides their therapeutic efficacy in diabetes, significant renoprotection was observed in non-diabetic patients with chronic kidney disease (CKD), suggesting the existence of glucose-independent beneficial effects of SGLT2 inhibitors. However, the relevant mechanisms by which ...


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