Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit

URN to cite this document:: urn:nbn:de:bvb:355-epub-522346
DOI to cite this document:: 10.5283/epub.52234

Sure, Florian ; Bertog, Marko ; Afonso, Sara ; Diakov, Alexei ; Rinke, Ralf ; Madej, M. Gregor

; Wittmann, Sabine ; Gramberg, Thomas ; Korbmacher, Christoph ; Ilyaskin, Alexandr V.

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Date of publication of this fulltext: 27 May 2022 14:52

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Abstract

The epithelial sodium channel (ENaC) is a heterotrimer consisting of α-, β- and γ-subunits. Channel activation requires proteolytic release of inhibitory tracts from the extracellular domains of α- and γ-ENaC; however, the proteases involved in the removal of the γ-inhibitory tract remain unclear. In several epithelial tissues, ENaC is coexpressed with the transmembrane serine protease 2 ...