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Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit

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Sure, Florian ; Bertog, Marko ; Afonso, Sara ; Diakov, Alexei ; Rinke, Ralf ; Madej, M. Gregor ; Wittmann, Sabine ; Gramberg, Thomas ; Korbmacher, Christoph ; Ilyaskin, Alexandr V.
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Date of publication of this fulltext: 27 May 2022 14:52


The epithelial sodium channel (ENaC) is a heterotrimer consisting of alpha-, beta-, and gamma-subunits. Channel activation requires proteolytic release of inhibitory tracts from the extracellular domains of alpha-ENaC and gamma-ENaC; however, the proteases involved in the removal of the gamma-inhibitory tract remain unclear. In several epithelial tissues, ENaC is coexpressed with the ...


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