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Gene regulation via nucleosome stability modulation and RNA:DNA triplex formation

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Wernig-Zorc, Sara
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ZIP Archive - Data
MST measurements and TSE-seq data
[img]License: Creative Commons Attribution 4.0
Date of publication of this fulltext: 17 Jul 2023 07:05

Abstract (English)

Gene regulation is a tightly controlled process in Eukaryotes. Coding and non-coding regions work together to ensure proper spatiotemporal gene expression through 3D chromatin organization, nucleosome positioning, histone tail post-translational modifications, epigenetic DNA modifications, and non-canonical nucleic acid structures such as RNA:DNA triplexes. In this thesis, I investigate two of ...


Translation of the abstract (German)

Die Genregulation ist ein genau kontrollierter Prozess in Eukaryonten. Kodierende und nicht-kodierende Regionen arbeiten zusammen, um eine korrekte räumlich-zeitliche Genexpression durch 3D-Chromatinorganisation, Nukleosomenpositionierung, posttranslationale Histonschwanzmodifikationen, epigenetische DNA-Modifikationen und nicht-kanonische Nukleinsäurestrukturen wie RNA:DNA-Triplexe ...


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