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Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

URN to cite this document:
urn:nbn:de:bvb:355-epub-524920
DOI to cite this document:
10.5283/epub.52492
Triebelhorn, Julian ; Cardon, Iseline ; Kuffner, Kerstin ; Bader, Stefanie ; Jahner, Tatjana ; Meindl, Katrin ; Rothhammer-Hampl, Tanja ; Riemenschneider, Markus J. ; Drexler, Konstantin ; Berneburg, Mark ; Nothdurfter, Caroline ; Manook, André ; Brochhausen, Christoph ; Baghai, Thomas C. ; Hilbert, Sven ; Rupprecht, Rainer ; Milenkovic, Vladimir M. ; Wetzel, Christian H.
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 24 Jun 2022 05:09

This publication is part of the DEAL contract with Springer.


Abstract

The molecular pathomechanisms of major depressive disorder (MDD) are still not completely understood. Here, we follow the hypothesis, that mitochondria dysfunction which is inevitably associated with bioenergetic disbalance is a risk factor that contributes to the susceptibility of an individual to develop MDD. Thus, we investigated molecular mechanisms related to mitochondrial function in ...

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