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Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

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Triebelhorn, Julian ; Cardon, Iseline ; Kuffner, Kerstin ; Bader, Stefanie ; Jahner, Tatjana ; Meindl, Katrin ; Rothhammer-Hampl, Tanja ; Riemenschneider, Markus J. ; Drexler, Konstantin ; Berneburg, Mark ; Nothdurfter, Caroline ; Manook, André ; Brochhausen, Christoph ; Baghai, Thomas C. ; Hilbert, Sven ; Rupprecht, Rainer ; Milenkovic, Vladimir M. ; Wetzel, Christian H.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 24 Jun 2022 05:09


The molecular pathomechanisms of major depressive disorder (MDD) are still not completely understood. Here, we follow the hypothesis, that mitochondria dysfunction which is inevitably associated with bioenergetic disbalance is a risk factor that contributes to the susceptibility of an individual to develop MDD. Thus, we investigated molecular mechanisms related to mitochondrial function in ...


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