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Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation

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Sorrentino, Antonio ; Menevse, Ayse Nur ; Michels, Tillmann ; Volpin, Valentina ; Durst, Franziska Christine ; Sax, Julian ; Xydia, Maria ; Hussein, Abir ; Stamova, Slava ; Spoerl, Steffen ; Heuschneider, Nicole ; Muehlbauer, Jasmin ; Jeltsch, Katharina Marlene ; Rathinasamy, Anchana ; Werner-Klein, Melanie ; Breinig, Marco ; Mikietyn, Damian ; Kohler, Christian ; Poschke, Isabel ; Purr, Sabrina ; Reidell, Olivia ; Martins Freire, Catarina ; Offringa, Rienk ; Gebhard, Claudia ; Spang, Rainer ; Rehli, Michael ; Boutros, Michael ; Schmidl, Christian ; Khandelwal, Nisit ; Beckhove, Philipp
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Date of publication of this fulltext: 01 Jul 2022 05:51


Background Cancer immunotherapeutic strategies showed unprecedented results in the clinic. However, many patients do not respond to immuno-oncological treatments due to the occurrence of a plethora of immunological obstacles, including tumor intrinsic mechanisms of resistance to cytotoxic T-cell (TC) attack. Thus, a deeper understanding of these mechanisms is needed to develop successful ...


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