Development of a Neurotensin-Derived 68Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS1 Receptor-Expressing Tumors

URN to cite this document:: urn:nbn:de:bvb:355-epub-530105
DOI to cite this document:: 10.5283/epub.53010

Schindler, Lisa ; Moosbauer, Jutta ; Schmidt, Daniel

; Spruss, Thilo ; Grätz, Lukas ; Lüdeke, Steffen ; Hofheinz, Frank ; Meister, Sebastian ; Echtenacher, Bernd ; Bernhardt, Günther

; Pietzsch, Jens

; Hellwig, Dirk

; Keller, Max

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Oct 2022 13:14

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Abstract

Overexpression of the neurotensin receptor type 1 (NTS1R), a peptide receptor located at the plasma membrane, has been reported for a variety of malignant tumors. Thus, targeting the NTS1R with 18F- or 68Ga-labeled ligands is considered a straightforward approach towards in vivo imaging of NTS1R-expressing tumors via positron emission tomography (PET). The development of suitable peptidic NTS1R ...