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Ceftazidime and cefepime antagonize 5-fluorouracil’s effect in colon cancer cells

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Pfab, Christina ; Abgaryan, Anush ; Danzer, Barbara ; Mourtada, Fatme ; Ali, Weaam ; Gessner, André ; El-Najjar, Nahed
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Date of publication of this fulltext: 13 Oct 2022 09:11


Background Drug-drug interaction (DDI), which can occur at the pharmacokinetics and/or the pharmacodynamics (PD) levels, can increase or decrease the therapeutic or adverse response of a drug itself or a combination of drugs. Cancer patients often receive, along their antineoplastic agents, antibiotics such as ss-lactams to treat or prevent infection. Despite the narrow therapeutic indices of ...


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