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Macrophages inhibit Coxiella burnetii by the ACOD1 ‐itaconate pathway for containment of Q fever

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Kohl, Lisa ; Siddique, Md Nur A. Alam ; Bodendorfer, Barbara ; Berger, Raffaela ; Preikschat, Annica ; Daniel, Christoph ; Ölke, Martha ; Liebler‐Tenorio, Elisabeth ; Schulze‐Luehrmann, Jan ; Mauermeir, Michael ; Yang, Kai‐Ting ; Hayek, Inaya ; Szperlinski, Manuela ; Andrack, Jennifer ; Schleicher, Ulrike ; Bozec, Aline ; Krönke, Gerhard ; Murray, Peter J. ; Wirtz, Stefan ; Yamamoto, Masahiro ; Schatz, Valentin ; Jantsch, Jonathan ; Oefner, Peter J. ; Degrandi, Daniel ; Pfeffer, Klaus ; Mertens‐Scholz, Katja ; Rauber, Simon ; Bogdan, Christian ; Dettmer, Katja ; Lührmann, Anja ; Lang, Roland
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Date of publication of this fulltext: 19 Dec 2022 06:52


Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis-aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti-microbial candidate genes, ...


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