Macrophages inhibit Coxiella burnetii by the ACOD1 ‐itaconate pathway for containment of Q fever

URN to cite this document:: urn:nbn:de:bvb:355-epub-534297
DOI to cite this document:: 10.5283/epub.53429

Kohl, Lisa ; Siddique, Md Nur A. Alam

; Bodendorfer, Barbara ; Berger, Raffaela

; Preikschat, Annica

; Daniel, Christoph ; Ölke, Martha ; Liebler‐Tenorio, Elisabeth ; Schulze‐Luehrmann, Jan ; Mauermeir, Michael ; Yang, Kai‐Ting

; Hayek, Inaya ; Szperlinski, Manuela ; Andrack, Jennifer ; Schleicher, Ulrike ; Bozec, Aline

; Krönke, Gerhard ; Murray, Peter J. ; Wirtz, Stefan ; Yamamoto, Masahiro ; Schatz, Valentin ; Jantsch, Jonathan ; Oefner, Peter J.

; Degrandi, Daniel ; Pfeffer, Klaus ; Mertens‐Scholz, Katja ; Rauber, Simon ; Bogdan, Christian ; Dettmer, Katja

; Lührmann, Anja ; Lang, Roland

License: Creative Commons Attribution 4.0
PDF - Published Version
(3MB)

Date of publication of this fulltext: 19 Dec 2022 06:52

Alternative links to fulltext:DOI Pubmed Publisher Publisher

Details

Preview

Export bibliographical data

Abstract

Infection with the intracellular bacterium Coxiella (C.) burnetii can cause chronic Q fever with severe complications and limited treatment options. Here, we identify the enzyme cis-aconitate decarboxylase 1 (ACOD1 or IRG1) and its product itaconate as protective host immune pathway in Q fever. Infection of mice with C. burnetii induced expression of several anti-microbial candidate genes, ...