Objectives The aim of the present study was to investigate the effects of a brief body-focused meditation on body ownership, while considering interoceptive abilities, dissociative experiences, mood, trait mindfulness, and meditation experience. Method The sample consisted of 111 healthy students who participated in a randomized controlled trial and either listened to a 20-min meditation or audio-book reading. Before and after the intervention, the rubber hand illusion and a heartbeat detection task were completed. The rubber hand illusion consisted of a synchronous and an asynchronous condition and the illusion intensity was measured using a questionnaire and by assessing the proprioceptive drift. In the heartbeat detection task, participants were instructed to count their heartbeats, so interoceptive accuracy of their counting, confidence in their own abilities (interoceptive sensibility), and the correspondence between both measures (interoceptive awareness) could be determined. Results The intervention type had no effect on mood and interoceptive abilities. Independent of intervention type, valence increased, arousal decreased, and interoceptive accuracy and interoceptive sensibility improved over time. Additionally, trait mindfulness and interoceptive accuracy were negatively related to the subjective rubber hand illusion intensity. There was not a mere effect of the intervention on the rubber hand illusion, but an interaction of synchrony, time, group, and interoceptive awareness was found for both measures, showing that only participants with high interoceptive awareness experienced a weaker illusion following the meditation. Conclusions We concluded that meta-awareness of interoceptive abilities may help protecting oneself against manipulations of the body boundaries.